/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

2 article(s) from Heilmann, Jörg

Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins

Guozheng Huang,
Simon Schramm,
Jörg Heilmann,
David Biedermann,
Vladimír Křen and
Michael Decker

Beilstein J. Org. Chem. 2016, 12, 662–669, doi:10.3762/bjoc.12.66

PDF

Graphical Abstract

Figure 1: Structures of silibinin, isosilybin, and silychristin, and hydnocarpin-type flavonolignans.

Jump to Figure 1

Figure 2: Synthetic strategy of semi-synthesis of hydnocarpins from silybins [22].

Jump to Figure 2

Scheme 1: Synthesis of ester derivatives of silibinin and conversion to hydnocarpin-type compounds. Reaction ...

Jump to Scheme 1

Figure 3: Putative mechanism of dehydration of flavanonols under Mitsunobu conditions.

Jump to Figure 3

Scheme 2: Attempt to dehydrate catechin. Reagents and conditions: a) p-nitrobenzoic acid, Ph₃P, DIAD, THF, rt...

Jump to Scheme 2

Scheme 3: Preparation of hydnocarpin (4) and isohydnocarpin (6) and attempt to dehydrate silydianin A (11). R...

Jump to Scheme 3

Album

Supp Info

Full Research Paper

Published 08 Apr 2016

Full text

Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view

Qiu Sun,
Jörg Heilmann and
Burkhard König

Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28

PDF

Graphical Abstract

Figure 1: Structure of 4-hydroxybenzyl alcohol (HBA, 1).

Jump to Figure 1

Figure 2: Structure–activity relationship of curcumin analogs.

Jump to Figure 2

Scheme 1: Synthesis of curcumin (3). Reagents and conditions: (a) vanillin, 1,2,3,4-tetrahydroquinoline, HOAc...

Jump to Scheme 1

Figure 3: Backbone and substitution of monocarbonyl analogs of curcumin (MACs) showing their structural diver...

Jump to Figure 3

Scheme 2: Exemplary synthesis of MAC representatives. Reagents and conditions: (a) 40% KOH, EtOH, 5 °C; stirr...

Jump to Scheme 2

Scheme 3: Synthesis of ellagic acid (7). Reagents and conditions: (a) H₂SO₄, CH₃OH; (b) (1) o-chloranil, Et₂O...

Jump to Scheme 3

Figure 4: Structure of resveratrol and its analogs.

Jump to Figure 4

Scheme 4: Synthesis of quinolone-substituted phenol 20. Reagents and conditions: (a) Ac₂O, 2-hydroxybenzaldeh...

Jump to Scheme 4

Scheme 5: Synthesis of quinolone-substituted phenol 23. Reagents and conditions: (a) Ac₂O, 2-hydroxybenzaldeh...

Jump to Scheme 5

Figure 5: Design of 4-amino-2-sulfanylphenol derivatives and their structure–activity relationship.

Jump to Figure 5

Scheme 6: Synthesis of 4-amino-2-sulfanylphenol derivatives. Reagents and conditions: (a) R¹SO₂Cl, pyridine, ...

Jump to Scheme 6

Figure 6: Structures of two series of natural-like acylphloroglucinols.

Jump to Figure 6

Scheme 7: Synthesis of acylphloroglucinol derivatives 35–41. Reagents and conditions: (a) acyl chloride, AlCl₃...

Jump to Scheme 7

Scheme 8: Synthesis of acylphloroglucinol derivatives 43–51. Reagents and conditions: (a) isoprene, Amberlyst...

Jump to Scheme 8

Figure 7: Analogs of (−)-EGCG for the prevention of oxidation and improvement of the bioavailability of the c...

Jump to Figure 7

Scheme 9: Synthesis of xanthohumol 58. Reagents and conditions: (a) MOMCl, diisopropylethylamine, CH₂Cl₂; (b)...

Jump to Scheme 9

Scheme 10: Synthesis of genistein 60. Reagents and conditions: (a) 4-hydroxyphenylacetonitrile, anhydrous HCl,...

Jump to Scheme 10

Scheme 11: Synthesis of fisetin (67) and quercetin (68). Reagents and conditions: (a) 3,4-dimethoxybenzaldehyd...

Jump to Scheme 11

Figure 8: Structure of (2S)-7,2’,4’-trihydroxy-5-methoxy-8-(dimethylallyl)flavanone (69).

Jump to Figure 8

Album

Review

Published 16 Feb 2015

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / Alerts / Privacy Policy / Terms & Conditions / Impressum